ENT 50852 - Names and Identifiers
Name | altretamine
|
Synonyms | RB-1515 WR-95704 ENT050852 ENT 50852 Aitretamine altretamine 2,4,6-tris(dimethylamino)-s-triazin 2,4,6-Tris(Dimethylamino)-s-triazine 1,3,5-tris(dimethylamino)-s-triazine 2,4,6-Tris(dimethylamino)-1,3,5-triazine 5-triazine-2,4,6-triamine,n,n,n',n',n'',n''-hexamethyl-3 5-triazine-2,4,6-triamine,n,n,n',n',n'',n''-hexamethyl-3 1,3,5-Triazine-2,4,6-triamine, N,N,N',N',N'',N''-hexamethyl-
|
CAS | 645-05-6
|
EINECS | 211-428-4 |
InChI | InChI=1/C9H24N6/c1-10(2)13-7-14(11(3)4)9-15(8-13)12(5)6/h7-9H2,1-6H3 |
ENT 50852 - Physico-chemical Properties
Molecular Formula | C9H18N6
|
Molar Mass | 210.28 |
Density | 1.0441 (rough estimate) |
Melting Point | 171-175 °C (lit.) |
Boling Point | 339.81°C (rough estimate) |
Water Solubility | Insoluble |
Solubility | Chloroform (Sparingly), Methanol (Slightly, Heated) |
Appearance | solid |
Color | White to Off-White |
Merck | 13,318 |
pKa | pKa 10.3 (Uncertain) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.6100 (estimate) |
Physical and Chemical Properties | White needle-like crystals. Melting point of 170-173 ° C, soluble in chloroform, methanol-soluble, ethanol-soluble, very slightly soluble in water, acid-base stability. With sublimation. |
In vitro study | Altretamine is an antineoplastic agent. |
In vivo study | Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells. |
ENT 50852 - Risk and Safety
Hazard Symbols | Xn - Harmful
|
Risk Codes | R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
WGK Germany | 3 |
RTECS | OS1050000 |
HS Code | 2933690000 |
Toxicity | LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper) |
ENT 50852 - Standard
Authoritative Data Verified Data
This product is 2,4, 6-tris (dimethylamino) S-triazine. The content of C9H18N6 shall not be less than 98.5% calculated as anhydrous.
Last Update:2024-01-02 23:10:35
ENT 50852 - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless; Can sublimate.
- This product is soluble in chloroform, slightly soluble in ethanol, insoluble in water; Soluble in dilute hydrochloric acid.
melting point
The melting point of this product (General 0612) is 170~174°C.
Last Update:2022-01-01 11:32:58
ENT 50852 - Differential diagnosis
Authoritative Data Verified Data
- take about 15mg of this product and add 5ml of 0.14% iodine petroleum ether solution. The color of the solution changes from purple to red.
- take this product and add anhydrous ethanol to make a solution containing 2ug per 1 ml. According to ultraviolet-visible spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 227nm.
- The infrared absorption spectrum of this product or its sublimation should be consistent with that of the control (Spectrum set 692).
Last Update:2022-01-01 11:32:58
ENT 50852 - Exam
Authoritative Data Verified Data
chlorine-containing compounds
take 0.10g of this product, precision weighing, according to oxygen flask combustion method (General rule 0703) for organic destruction, with sodium hydroxide test solution 2ml and water 10ml as absorption liquid, once the combustion is completed, fully shake to make the absorption completely, Add 10ml of dilute nitric acid, move into 50ml Nessler's Cuvette, check according to law (Appendix 0801), and compare with the control solution made of standard sodium chloride solution 1.0mL by the same method, no more concentrated (0.01%).
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 0.5%.
ignition residue
not more than 0.1% (General rule 0841).
Last Update:2022-01-01 11:32:59
ENT 50852 - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add glacial acetic acid and acetic anhydride each 10ml to dissolve, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 21.03mg of C9Hl8N6.
Last Update:2022-01-01 11:32:59
ENT 50852 - Category
Authoritative Data Verified Data
Last Update:2022-01-01 11:32:59
ENT 50852 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update:2022-01-01 11:33:00
ENT 50852 - Hexamethylmelamine tablets
Authoritative Data Verified Data
This product contains hexamethylenediamine (C9H18N6) should be 90.0% to 110.0% of the label amount.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.lg of hexamethylmelamine), add an appropriate amount of chloroform, shake to dissolve hexamethylmelamine, filter, and evaporate the filtrate to dryness on a water bath, the residue was identified according to the test of item (1) and item (2) under the item of hexamethylmelamine, showing the same result.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (0.9-1000) 900ml as the dissolution medium, speed of 100 revolutions per minute, according to the law of operation, after 30 minutes, take the solution 10ml, with 0.45um filter membrane filtration, precision take filtrate 2ml, put 25ml( 50mg specifications) or 50ml ( lOOmg specification) measuring flask, dilute to scale with dissolution medium, shake well, as a test solution; Another reference substance of hexamethylmelamine, precision weighing, add hydrochloric acid solution (0.9-1000) to dissolve and quantitatively dilute to prepare a solution containing about 4.4ug per 1 ml as a reference solution; Take the above two solutions, the elution amount of each tablet was calculated by measuring the absorbance at a wavelength of 241mn according to ultraviolet-visible spectrophotometry (General rule 0401). The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Ammonium carbonate solution [take ammonium carbonate 0.79g, add water 1000ml to dissolve, with formic acid solution (1-10) or ammonia solution (1-10) To adjust the pH value to 8.0±0.05]-methanol (25:75) as mobile phase; Detection wavelength is 227nm. The number of theoretical plates shall not be less than 2500 as calculated from the peak of hexamethylmelamine.
- determination of 20 tablets of this product, precision weighing, fine, precision weighing an appropriate amount (about 25mg equivalent to hexamethylmelamine), put it in a 50ml measuring flask, add methanol 35ml, shake to dissolve hexamethylmelamine, dilute to the scale with water, shake well, filter, Take 5ml of continuous filtrate accurately, put it in 50 ml measuring flask, use methanol-water (65:35) dilute to the scale, shake, as a test solution, take 10 u1, inject into the liquid chromatograph, record the chromatogram; Take about 25mg of the reference substance of hexamethylmelamine, put 50 ml measuring flask, add methanol 35ml, shake to dissolve, dilute with water to scale, shake well, take 5ml, put 50 ml measuring flask, use methanol-water (65:35) diluted to the scale, shake, the same method. According to the external standard method to calculate the peak area, that is.
category
Same as hexamethylmelamine.
specification
(l)50mg (2)100mg
storage
light shielding, sealed storage.
Last Update:2022-01-01 11:33:01
ENT 50852 - Hexamethylmelamine capsules
Authoritative Data Verified Data
This product contains hexamethylenediamine (C9H18N6) should be 90.0% to 110.0% of the label amount.
trait
The content of this product is white or white powder.
identification
take an appropriate amount of the content of this product (about 0.lg equivalent to hexamethylmelamine), add an appropriate amount of chloroform, shake to dissolve hexamethylmelamine, filter, and evaporate the filtrate to dryness on a water bath, the residue was identified according to the test of item (1) and item (2) under the item of hexamethylmelamine, showing the same result.
examination
- dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (0.9-1000)900ml as the dissolution medium, speed of 100 revolutions per minute, according to the law, after 30 minutes, take the solution 10ml, filtered, precision take the filtrate 2ml, set 25ml ( 50mg specifications) or 50ml ( lOOmg specifications) or 100ml ( 200mg specification) measuring flask, dilute to the scale with dissolution medium, shake well, as a test solution; Another reference substance of hexamethylmelamine, precision weighing, add hydrochloric acid solution (0.9-1000) to dissolve and quantitatively dilute to prepare a solution containing about 4.4 tons per 1 ml as a reference solution; Take the above two solutions, the absorbance was measured at a wavelength of 0401 NM according to UV-Vis spectrophotometry (general rule), and the amount of each particle dissolved was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
The contents under the loading amount difference item were mixed evenly, and an appropriate amount (corresponding to about 0.15g of hexamethylmelamine) was accurately weighed and measured according to the method under the hexamethylmelamine item.
category
Same as hexamethylmelamine.
specification
(l)50mg (2) lOOmg (3)200mg
storage
light shielding, sealed storage.
Last Update:2022-01-01 11:33:01